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. 2005 Nov 1;115(11):3035–3044. doi: 10.1172/JCI25681

Figure 2.

Figure 2

Plasma leptin and hypothalamic AgRP and NPY expression were decreased following GM-CSF treatment. (A) Rats were given i3vt injections of vehicle or GM-CSF and then fed, fasted (Fast), or pair-fed (Prfed) for 24 hours. In fed rats, GM-CSF treatment decreased leptin levels compared with vehicle treatment. Fasted groups did not differ despite treatment and were similar to a pair-fed group. *P < 0.05; n = 7–9; mean ± SEM. (B) AgRP and NPY expression in hypothalamus was decreased in fasted rats killed after receiving 2 daily injections of GM-CSF. *P < 0.05; n = 5–7; mean ± SEM.