Skip to main content
. 2005 Nov 1;115(11):3035–3044. doi: 10.1172/JCI25681

Figure 4.

Figure 4

Peripheral administration of GM-CSF to rats. Rats received i.p. injection of vehicle or 6 μg GM-CSF or i3vt injection of vehicle or 0.6 μg GM-CSF. (A) Twenty-four-hour food intake did not differ among animals receiving i.p. vehicle, i.p. 6 μg GM-CSF, or i3vt vehicle. Food intake was decreased in rats receiving i3vt 0.6 μg GM-CSF. (B) Similarly, body weight was decreased in rats treated with 0.6 μg i3vt GM-CSF but not those treated with i3vt vehicle or injected i.p. with either GM-CSF or vehicle. (C) Subcutaneous injection of 30 μg/kg GM-CSF resulted in increased serum GM-CSF levels at 1, 2, and 4 hours after injection. GM-CSF levels were below the limit of detection at time point 0 in GM-CSF–injected rats (squares) and at all time points in vehicle-treated rats (triangles). At 24 hours after s.c. injection, body weight change in rats receiving 30 mg/kg GM-CSF did not differ from that in rats receiving vehicle (C, inset), and food intake did not differ for at least 3 days (D). *P < 0.05; n = 7 to 9; mean ± SEM.