Table 2.

Comparison of the activation and deactivation kinetics of TRPV1. Mean activation and deactivation rates of responses from TRPV1 expressing HEK-293 cells following application of capsaicin (1 μM), acidic pH (5.5) or the combination. Row 3 represents activation and deactivation rates of currents evoked by 1 μM capsaicin following pre-exposure to acidic conditions (pH 5.5). Row 4 represents the activation rates of acid-evoked currents following pre-exposure to capsaicin (1 μM). The absolute value of rate measurements had slight day-to-day variations (possibly due to relative position of the drug application tube). Therefore values in this table are from cells in which direct comparisons can be made. Values are mean ± S.E.M.

	Activation Rates		Deactivation Rates
	τ (ms)	n	τ (ms)	n
1 μM Capsaicin	847 ± 119	4	845 ± 60	4
pH 5.5	917 ± 307	3	56 ± 13	4
1 μM CAP (pH 5.5)	149.3 ± 17	4	10553 ± 1880	4
pH 5.5 (1 μM CAP)	93 ± 13	3	-not tested-

Note: Rates from experiments shown in Figures 4 and 5.