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Replicative life span of oral keratinocytes additionally overexpressing EGFR and c-myc. Growth characteristics of OKF6-D1/dnp53, OKF6-D1/dnp53/EGFR, OKF6-D1/dnp53/EGFR plus EGF, and OKF6-D1/dnp53/EGFR/c-myc cells (a), as well as OKM1, OKM1-D1/dnp53, OKM1-D1/dnp53/EGFR, OKM1-D1/dnp53/EGFR plus EGF, and OKM1-D1/dnp53/EGFR/c-myc cells (b) are displayed. The replicative life span was assessed by calculating the PD values.
