Table 1. Brachiocephalic artery morphometry in chow-fed apoE/MMP double knockout mice.
| Study group | Lumen area, ×103 μm2 | Media area, ×103 μm2 | Total vessel area, ×103 μm2 | Internal elastic lumina length, μm |
|---|---|---|---|---|
| ApoE-/-/MMP-3+/+ (n = 6) | 149 ± 15 | 70 ± 3 | 218 ± 17 | 1,364 ± 69 |
| ApoE-/-/MMP-3-/- (n = 6) | 147 ± 13 | 67 ± 7 | 214 ± 20 | 1,358 ± 59 |
| ApoE-/-/MMP-7+/+ (n = 6) | 185 ± 12 | 60 ± 4 | 245 ± 14 | 1,521 ± 51 |
| ApoE-/-/MMP-7-/- (n = 6) | 196 ± 13 | 57 ± 8 | 254 ± 19 | 1,568 ± 52 |
| ApoE-/-/MMP-9+/+ (n = 6) | 156 ± 11 | 59 ± 5 | 239 ± 25 | 1,481 ± 85 |
| ApoE-/-/MMP-9-/- (n = 6) | 179 ± 21 | 59 ± 7 | 215 ± 18 | 1,396 ± 85 |
| ApoE-/-/MMP-12+/+ (n = 6) | 168 ± 9 | 48 ± 4 | 202 ± 13 | 1,385 ± 52 |
| ApoE-/-/MMP-12-/- (n = 6) | 153 ± 12 | 57 ± 3 | 225 ± 10 | 1,449 ± 39 |
Double knockout mice and single knockout controls were fed chow diet and terminated at 6 weeks of age, and the brachiocephalic artery was removed. Vessel compartment areas were determined by computerized morphometry. There were no significant differences between double knockout and single knockout control mice. Values represent mean ± SEM.