Table 2. Plasma lipids in fat-fed apoE/MMP double knockout mice.
| Study group | Total cholesterol, mmol/liter | High-density lipoprotein cholesterol, mmol/liter | Low-density lipoprotein cholesterol, mmol/liter | Triglycerides, mmol/liter |
|---|---|---|---|---|
| ApoE-/-/MMP-3+/+ (n = 26) | 32.9 ± 2.2 | 2.5 ± 0.1 | 29.3 ± 2.2 | 2.2 ± 0.5 |
| ApoE-/-/MMP-3-/- (n = 26) | 31.7 ± 3.0 | 2.7 ± 0.1 | 28.1 ± 2.7 | 1.9 ± 0.4 |
| ApoE-/-/MMP-7+/+ (n = 24) | 29.0 ± 3.1 | 2.1 ± 0.2 | 26.2 ± 2.8 | 2.9 ± 0.7 |
| ApoE-/-/MMP-7-/- (n = 20) | 28.6 ± 2.5 | 2.3 ± 0.2 | 25.5 ± 2.2 | 2.0 ± 0.6 |
| ApoE-/-/MMP-9+/+ (n = 24) | 32.4 ± 1.4 | 2.9 ± 0.1 | 28.6 ± 1.3 | 1.8 ± 0.2 |
| ApoE-/-/MMP-9-/- (n = 25) | 27.6 ± 3.1 | 2.6 ± 0.3 | 23.8 ± 2.6 | 2.6 ± 0.7 |
| ApoE-/-/MMP-12+/+ (n = 21) | 36.7 ± 2.9 | 2.9 ± 0.2 | 33.2 ± 2.4 | 1.4 ± 0.3 |
| ApoE-/-/MMP-12-/- (n = 20) | 43.4 ± 1.1 | 3.5 ± 0.1* | 37.9 ± 1.0 | 4.2 ± 0.4* |
Double knockout mice and single knockout controls were fed a high-fat diet for 8 weeks then plasma lipid analyses were performed on terminal bloods drawn from the abdominal aorta. Values represent mean ± SEM. *, P < 0.01 versus single knockout control.