Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
p53 mRNA expression and p53 mutations in microdissected synovial tissues. Microdissected regions from eight RA patients were analyzed for p53 expression and mutations. The percentage of p53 mRNA positive regions by reverse transcriptase–PCR was significantly higher in the lining compared with the sublining (P < 0.01). The percentage of regions with a high mutation rate (i.e., >15% of subclones) was significantly higher in the lining compared with the sublining (P < 0.01).
