Table 1.

Pyrogenicity and lethality of rSpeK and rSSA

Toxin	Pyrogenicity* (Avg. change, °C)	Models of lethality (No. dead per no. total animals)
		Endotoxin† enhancement	Miniosmotic‡ pump
rSpeK	+1.3	3/3	2/3
rSSA	+1.4	3/3	3/3
rTSST-1	+0.9	3/3	3/3
PBS	−0.1	0/3	ND§

^*Animals were injected intravenously with 5 μg/kg of recombinant protein at 0 h, and temperatures were recorded at 4 h. Three rabbits were used for all assays with the exception of rTSST-1, in which six were used. 

^† Mortality was recorded for a 48-h period after 10 μg/kg endotoxin injection. 

^‡ Mortality was recorded for 15 days after subcutaneous implantation of pump. 

^§ Not determined.