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. 2002 Jul 10;99(15):10084–10089. doi: 10.1073/pnas.152059399

Figure 3.

Figure 3

Identification of the LMP1 domain critical for E-cadherin promoter regulation. (A) Schematic representation of LMP1 and its mutant constructs. The Src homology 3 (SH3)-like domain, CTAR1 and CTAR2 are indicated. (B) Regulation of pEcad−164/+49 by LMP1 and its mutants. Individual LMP1-expressing constructs were cotransfected with the pEcad−164/+49, and relative luciferase activity was determined and normalized as described in Materials and Methods. The percentage of promoter activity in each transfection was determined with respect to the vector control value, taken as 100%. The LMP1 protein in each transfection was determined by Western blotting analysis using α-flag antibody, M5 (Sigma).