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Activation of the transcription of ISRE-controlled genes by influenza B virus is not mediated by IFN-α/β and does not require the synthesis of viral proteins. GRE cells were either mock-infected (−) or were infected with influenza B virus (B) in the absence or presence of 100 μg/ml of CM for 4 h. Northern blot analysis was used to detect either only p56 mRNA (A) or both p56 and ISG15 mRNAs (B).
