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. 2005 Oct 14;5:83. doi: 10.1186/1471-2334-5-83

Figure 1.

Figure 1

HPV-16 integrations during oncogenesis. In normal HPV-16 infections the HPV-16 genome is present as an episome. The mRNAs that encode the HPV-16 E6 and E7 oncogenes are transcribed by the main promoter, spliced from the 880 splice donor and uses the early polyadenylation signal. During cervical oncogenesis the HPV-16 genome is integrated into the cellular genome. This integration occurs in the E1/E2 region and leads to generation of chimeric mRNAs that encode E6 and E7. Most often the chimeric mRNAs are of the A type that are spliced to a cellular splice acceptor [14].