Table 3.
Statistical significance of serum fasting glucose level and lipid profile in diabetic-hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives.
| Parameters | C | C+B | C+Q | C+BrQ | C+IQ |
| Glucose(mg/dl) | |||||
| Mean ± SD | 210.34 ± 16.56a | 173.82 ± 26.86b | 68.40 ± 5.22c | 71.32 ± 8.42c | 68.60 ± 5.66c |
| Range | (189.24–230.00) | (140.00–218.00) | (61.65–79.47) | (60.55–85.00) | (60.76–75.36) |
| Change% | - | -17.36 | -67.48 | -66.09 | -67.39 |
| Total lipids(g/L) | |||||
| Mean ± SD | 6.25 ± 2.29a | 4.76 ± 0.85b | 3.23 ± 1.08c | 3.14 ± 0.63c | 3.28 ± 0.77c |
| Range | (2.32–9.51) | (3.76–5.96) | (2.02–4.64) | (2.02–4.15) | (2.20–4.34) |
| Change% | - | -23.84 | -48.32 | -49.76 | -47.52 |
| T.G(mg/dl) | |||||
| Mean ± SD | 110.42 ± 18.75a | 91.91 ± 15.64a | 109.51 ± 31.98a | 99.00 ± 15.06a | 100.64 ± 10.33a |
| Range | (88.14–133.33) | (70.00–111.11) | (66.67–165.00) | (73.33–121.14) | (86.67–117.11) |
| Change% | - | -16.76 | -0.82 | -10.34 | -9.72 |
| T.Cholesterol(mg/dl) | |||||
| Mean ± SD | 176.28 ± 42.14a | 152.76 ± 36.36a | 99.31 ± 22.80b | 88.38 ± 26.64b | 89.69 ± 10.02b |
| Range | (127.34–224.38) | (106.25–199.22) | (74.22–126.56) | (65.63–134.38) | (73.44–104.22) |
| Change% | - | -13.34 | -43.66 | -49.86 | -49.12 |
| F.Cholesterol(mg/dl) | |||||
| Mean ± SD | 39.19 ± 11.02ab | 44.37 ± 9.44a | 30.31 ± 6.98b | 30.03 ± 6.73b | 31.06 ± 5.43b |
| Range | (25.62–51.89) | (28.62–53.98) | (20.16–40.98) | (23.09–41.30) | (26.02–41.63) |
| Change% | - | 13.22 | -22.66 | -23.37 | -20.75 |
| E.Cholesterol(mg/dl) | |||||
| Mean ± SD | 135.37 ± 31.41a | 108.39 ± 31.2b | 69.00 ± 18.80c | 60.46 ± 16.43c | 58.56 ± 6.96c |
| Range | (101.72–170.75) | (77.63–145.24) | (49.18–96.97) | (48.40–88.08) | (47.42–65.67) |
| Change% | - | -19.93 | -62.33 | -55.34 | -56.74 |
| HDL-C(mg/dl) | |||||
| Mean ± SD | 24.76 ± 3.62a | 25.88 ± 2.74a | 24.87 ± 4.71a | 26.71 ± 2.58a | 22.50 ± 1.77a |
| Range | (18.00–27.94) | (21.13–29.60) | (19.83–31.52) | (22.40–30.33) | (19.80–24.32) |
| Change% | - | 4.52 | 0.44 | 7.88 | -9.13 |
| LDL-C(mg/dl) | |||||
| Mean ± SD | 115.29 ± 34.06a | 84.56 ± 43.44a | 32.58 ± 18.85b | 39.56 ± 26.65b | 45.26 ± 10.16b |
| Range | (79.73–168.69) | (44.05–137.56) | (19.51–64.94) | (16.24–82.42) | (34.31–63.03) |
| Change% | - | -26.65 | -71.74 | -65.69 | -60.74 |
| VLDL-C(mg/dl) | |||||
| Mean ± SD | 22.08 ± 3.75a | 18.38 ± 3.13a | 22.52 ± 6.28a | 19.80 ± 3.01a | 20.13 ± 2.07a |
| Range | (17.63–26.67) | (14.00–22.22) | (13.33–33.00) | (14.67–24.23) | (17.33–23.42) |
| Change% | - | -1.67 | 1.99 | -10.33 | -8.83 |
| A.I. | |||||
| Mean ± SD | 6.27 ± 2.06a | 4.49 ± 1.53b | 3.12 ± 1.20b | 1.91 ± 1.27b | 3.01 ± 0.57b |
| Range | (3.56–9.80) | (2.59–6.91) | (1.65–4.82) | (0.99–4.33) | (2.21–3.79) |
| Change% | - | -28.39 | -50.24 | -69.54 | -51.99 |
For each parameter similar characters denote insignificance between groups.
The mean difference is significant at p < 0.05.