Figure 1.

Essential cellular processes required for maintenance of mitochondrial morphology. Promoter shutoff strains (n = 768) lacking essential gene products were screened for mutants with aberrant mitochondrial morphology. Of these strains, 15% showed strong defects in mitochondrial morphology and distribution (average, indicated by dotted line). Black columns indicate functional classes that contained a high percentage of mutants with disorganized mitochondria. In case of protein degradation factors, genes encoding proteasome subunits were counted separately (white column). Light gray columns represent genes of unknown function, and genes of known functions other than that included in the black columns. A complete list of screened yeast strains can be found in Supplementary Table 1.