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. 2025 Nov 17;12:1662177. doi: 10.3389/fmed.2025.1662177

Table 2.

Differences between patients having a Fluid Retention Index (FRI) of >4.0 on admission to hospital as evidence of strong renal water conservation before the surgery.

FRI ≤ 4.0
(N = 857)
FRI > 4.0
(N = 64)
Odds ratio or difference (95% CI) P-value
FRI (mean score) 2.1 ± 0.9 4.7 ± 0.5 2.58 (2.35–2.81) <0.001
Age (yr) 61.3 ± 11.9 52.6 ± 12.6 8.92 (5.85–12.0) <0.001
Females (%) 48 34 0.58 (0.34–0.98) 0.049
ASA I, II, III* 78/20/2 80/16/4 0.12
Infused ringer
Volume (mL) 1,974 ± 708 2,320 ± 848 345 (161–529) <0.001
>3 L (%) 5.7 14.3 2.75 (1.28–5.89) 0.007
Infused Voluven (mL)
Incidence (%) 93% 94% 0.85
Volume (mL) 551 ± 177 717 ± 250 151 (75–228) 0.001
Urine (mL) 380 (200–600) 200 (118–500) 100 (50–170) 0.003
Urine flow (mL/min) 1.6 (0.9–2.5) 0.9 (0.6–1.7) 0.70 (0.23–1.21) <0.001
Baseline (mmHg) 92 ± 12 89 ± 10 3.4 (0.4–6.4) 0.03
Surgery/baseline (ratio) 0.95 ± 0.14 1.01 ± 0.17 0.062 (0.39–1.05) 0.002
Blood loss
Volume (mL) 80 (50–120) 100 (30–170) 42 (10–73) 0.01
>500 mL (%) 1 5 4.86 (1.28–18.43) 0.04
Extubation time (min) 27 (18–40) 30 (21–50) 5 (1–10) 0.001
P-glucose (mmol/L)
Baseline 5.0 ± 0.6 5.1 ± 0.5 0.47
Postoperative 6.6 ± 1.8 5.8 ± 1.6 0.88 (0.33–1.43) 0.006
P-creatinine (μmol/L)
Baseline 65.6 ± 13.7 63.5 ± 14.2 0.21
Change (%) +0.7 ± 16.0 −4.4 ± 16.0 3.42 (0.61–6.24) 0.017
Paralytic ileus (days) 1.5 ± 1.3 2.4 ± 2.3 0.81 (0.46–1.16) 0.001
Food intolerance (days) 2.4 ± 2.3 3.9 ± 3.2 1.52 (0.70–2.35) 0.011
Infection (%)
Respiratory 21 19 0.87 (0.46–1.67) 0.72
Wound 10 17 1.99 (1.00–3.96) 0.046
Fever 17 28 1.89 (1.07–3.35) 0.03

The statistical test was one-way ANOVA or the Mann–Whitney’s U test depending on data distribution. Categorical data were evaluated by the chi-square test. Bonferroni correction of the p-values to account for multiple testing was applied.

FRI, Fluid Retention Index; MAP, mean arterial pressure; ASA, American Society of Anesthesiologists (scale for physical health).

*

The inclusion of ASA class III is a protocol violation.