TABLE 2.
Summary of molecular subtypes identified in this study and their comparison with ALLIC-BFM-2009 frequencies (Campbell et al., 2023).
| Study | ||||
|---|---|---|---|---|
| GATLA-2010 n = 32 | ALLIC-BFM-2009 n = 6,187 | |||
| B-ALL subtype | GATLA | ALLSorts | Final classification | |
| B-other/unclassified | 12 (37.5%) | 2 (6.3%) | 2 (6.3%) | 582 (9.4%) |
| BCL2/MYC | N/A | 0 (0%) | 0 (0%) | N/A |
| DUX4 | N/A | 5 (15.6%) | 4 (13%) a | N/A |
| Hyperdiploid | 8 (25%) | 12 (38%) | 12 (38%) a | 762 (12.3%) |
| DUX4/Hyperdiploid | na | na | 1 (3.1%) a | na |
| ETV6::RUNX1 | 2 (6.2%) | 3 (9.4%) | 3 (9.4%) | 845 (13.7%) |
| ETV6::RUNX1-like | N/A | 2 (6.3%) | 2 (6.3%) | N/A |
| HLF | N/A | 0 (0%) | 0 (0%) | N/A |
| iAMP21 | N/A | 0 (0%) | 0 (0%) | N/A |
| IKZF1 N159Y | N/A | 0 (0%) | 0 (0%) | N/A |
| KMT2A | 0 (0%) | 0 (0%) | 0 (0%) | 36 (0.6%) |
| KMT2A-like | N/A | 0 (0%) | 0 (0%) | N/A |
| Low hypodiploid | 0 (0%) | 0 (0%) | 0 (0%) | 47 (0.8%) |
| MEF2D | N/A | 1 (3.1%) | 1 (3.1%) | N/A |
| Near haploid | 0 (0%) | 0 (0%) | 0 (0%) | N/A |
| NUTM1 | N/A | 0 (0%) | 0 (0%) | N/A |
| PAX5 P80R | N/A | 0 (0%) | 0 (0%) | N/A |
| PAX5alt | N/A | 2 (6.3%) | 2 (6.3%) | N/A |
| Ph | 0 (0%) | 0 (0%) | 0 (0%) | 79 (1.3%) |
| Ph-like | N/A | 3 (9.3%) | 3 (9.4%) | N/A |
| TCF3::PBX1 | 0 (0%) | 1 (3.1%) | 1 (3.1%) | N/A |
| ZNF384 | N/A | 1 (3.1%) | 1 (3.1%) | N/A |
| Not done/no results | 10 (31.2%) | 0 (0%) | 0 (0%) | 3,836 (62%) |
a
One sample was classified as DUX4 (ALLSorts) and as Hyperdiploid (karyotyping). We categorized it as DUX4/Hyperdiploid. consequently, the total number of samples in DUX4 and Hyperdiploid subtypes is one less than expected, as this sample was counted in the DUX4/Hyperdiploid category. N/A: not available; na: not applicable.