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. 2025 Nov 28;11(4):e003052. doi: 10.1136/bmjsem-2025-003052

Table 2. Summary of primary outcomes and time points of measurements.

Primary outcomes
Outcome Parameter Description Data recording
Cardiovascular outcomes
Cardiac autonomic control Time domain SDNN SD of all NN intervals (ms) 5 min epochs
RMSSD Square root of the mean of the sum of the squares of differences between adjacent NN intervals (ms)
Frequency domain LF Power of the low frequency range in absolute values (ms2)
HF Power of the high frequency range in absolute values (ms2)
LF n.u. Power of the low frequency range in normalised units
HF n.u. Power of the high frequency range in normalised units
Ratio LF/HF Ratio
Entropy AmpEn Approximate entropy
SampEn Sample entropy
Cardiac baroreflex BRScount Number of baroreflex sequences detected (n) 10 min epochs
BRSslope Magnitude of the baroreflex sensitivity (ms·mm Hg−1)
BEI Baroreflex effectiveness index (%)
Sympathetic vasomotor tone LFsBP Low frequency of systolic blood pressure (mm Hg2)
Haemodynamics SBP Systolic blood pressure (mm Hg)
DBP Diastolic blood pressure (mm Hg)
MAP Mean arterial pressure (mm Hg)
HR Heart rate (bpm)
RPP Rate pressure product (bpm·mm Hg)
Arterial stiffness f-t PWV ft-PWV Finger-toe pulse wave velocity (m·s−1) Single assessment
f-t TT; ft-TT Finger-toe transit time (ms)
Resting metabolic outcomes
Metabolic responses VO2 Oxygen uptake (mL·kg−1·min−1) 10 min epochs
VCO2 Carbon dioxide production (mL·kg−1·min−1)
RER Respiratory exchange ratio