Fig. 8.
RNA-seq analysis revealing the potential mechanize of H2 promoting STI. (A) Schematic illustration of H2 activating the MAPK signaling pathway in HGFs and HUVECs to promote cell proliferation, and enhancing the secretion of paracrine angiogenic cytokines by HGFs to induce angiogenesis. (B) The volcano plot depicting different expressed genes between HP-MTi and P-MTi. (C) GO enrichment analysis revealing the up-regulated terms between HP-MTi and P-MTi. GSEA analysis of (D) the positive regulation of cell proliferation and (E) angiogenesis. (F) KEGG enrichment analysis revealing the up-regulated pathways between HP-MTi and P-MTi. (G) Visualizing the top ten significantly enriched pathways and their corresponding differentially expressed genes through KEGG enrichment analysis with a chord diagram. (H)GSEA analysis of MAPK signaling pathway. (I) Heat map of differential expressed genes associated with the MAPK signaling pathway.