Table 1. Summary of EC₅₀ and CC₅₀ data.

Compound	Target	Cell	EC50	CC50	SI*
MCCB5	WT	BSR-T7	4.4†‡	>100	22.7
MCCB5	WT	Huh7-Lunet-T7	10.4†	80	7.6
MCCb5	F280A	BSR-T7	13.8	nd	nd
MCCB5	L284A	BSR-T7	15.0	nd	nd
MCCB5	V250A	BSR-T7	15.4	nd	nd
CB6	WT	BSR-T7	0.19†‡	>100	526
CB6	WT	Huh7-Lunet-T7	0.41†	>100	222
CB6	F280A	BSR-T7	2.5	nd	nd
CB6	L284A	BSR-T7	2.6	nd	nd
CB6	V250A	BSR-T7	31	nd	nd
MJM364	WT	BSR-T7	0.84†‡	>100	119
MJM364	WT	Huh7-Lunet-T7	1.2†	18.8	15.6
MJM364	F280A	BSR-T7	8.6	nd	nd
MJM364	L284A	BSR-T7	8.6	nd	nd
MJM364	V250A	BSR-T7	6.9	nd	nd

*Selective index (CC₅₀/EC₅₀).

†Unpaired two-tailed t-test of significance between EBOV and T7FFLuc control. ****P<0.0001.

‡Unpaired two-tailed t-test of significance between EBOV and BUNV control. ****P<0.0001.

nd, not determined.