Table 3.
Comparison of secondary outcomes between patients treated with rt-PA and patients treated with TNK
| Overall (n = 138) | All patients (n = 138) | rt-PA group (n = 65) | TNK group (n = 73) | p-value |
|---|---|---|---|---|
| NIHSS 24 h (median (IQR)) | 3 (8–1) | 3 (6.3–1) | 3 (8–1) | 0.685 |
| NIHSS discharge (median (IQR)) | 1 (3–0) | 1 (3–1) | 2 (3.3–0) | 0.909 |
| mRS discharge (median (IQR)) | 2 (3–1) | 2 (3–1) | 2 (3–1) | 0.479 |
| mRS 0–1 discharge (n (%)) | 57 (41.3) | 26 (40.0) | 31 (42.3) | 0.769 |
| mRS 0–2 discharge (n (%)) | 82 (59.4) | 42 (64.6) | 40 (54.8) | 0.241 |
| Subgroup of patients with EVT ( n = 41) | ( n = 41) | ( n = 24) | (n = 17) | |
| NIHSS 24 h (median (IQR)) | 5.5 (11–2) | 4 (10.5–2) | 8 (12–3) | 0.323 |
| NIHSS discharge (median (IQR)) | 2 (3.3–1) | 2 (3.5–1) | 2 (3–1) | 0.724 |
| mRS discharge (median (IQR)) | 2 (4–1) | 2 (3–1) | 3 (4–1) | 0.194 |
| mRS 0–1 discharge (n (%)) | 17 (41.5) | 10 (41.7) | 7 (41.2) | 0.975 |
| mRS 0–2 discharge (n (%)) | 23 (56.1) | 15 (62.5) | 8 (47.1) | 0.326 |
| Subgroup of patients with EVT ( n = 97) | ( n = 97) | ( n = 41) | ( n = 56) | |
| NIHSS 24 h (median (IQR)) | 3 (5–1) | 2 (6–1) | 3 (5–1) | 0.698 |
| NIHSS discharge (median (IQR)) | 1 (3–0) | 1 (3–0) | 2 (3.5–0) | 0.950 |
| mRS discharge (median (IQR)) | 2 (3–1) | 2 (3–1) | 2 (3–1) | 0.852 |
| mRS 0–1 discharge (n (%)) | 40 (41.2) | 16 (39.0) | 24 (42.9) | 0.705 |
| mRS 0–2 discharge (n (%)) | 59 (60.8) | 27 (65.9) | 32 (57.1) | 0.385 |
rt-PA Alteplase, TNK Tenecteplase, NIHSS National Institutes of Health Stroke Scale, mRS Modified Rankin Scale, IQR Interquartile range, EVT Endovascular thrombectomy
Numbers written in bold indicate statistically significant group comparisons