Table 4.
Comparison of safety outcomes between patients treated with rt-PA and patients treated with TNK
| Overall (n = 139) | All patients (n = 139) | rt-PA group (n = 65) | TNK group (n = 74) | p-value |
|---|---|---|---|---|
| Any ICH within 24 h (n (%)) | 17 (12.2) | 7 (10.8) | 10 (13.5) | 0.601 |
| sICH (n (%)) | 6 (4.3) | 1 (1.5) | 5 (6.8) | 0.213 |
| Parenchymal hematoma (PH 2) | 3 (2.2) | 0 (0.0) | 3 (4.1) | 0.248 |
| Death by day 7 (n (%)) | 9 (6.5) | 2 (3.1) | 7 (9.5) | 0.172 |
| Subgroup of patients with EVT ( n = 41) | ( n = 41) | ( n = 24) | ( n = 17) | |
| Any ICH within 24 h (n (%)) | 10 (24.4) | 5 (20.8) | 5 (29.4) | 0.529 |
| sICH (n (%)) | 4 (9.8) | 1 (4.2) | 3 (17.6) | 0.290 |
| Parenchymal hematoma (PH 2) | 2 (4.9) | 0 (0.0) | 2 (11.8) | 0.455 |
| Death by day 7 (n (%)) | 4 (9.8) | 1 (4.2) | 3 (17.6) | 0.290 |
| Subgroup of patients with EVT ( n = 98) | ( n = 98) | ( n = 41) | ( n = 57) | |
| Any ICH within 24 h (n (%)) | 7 (7.1) | 2 (4.9) | 5 (8.8) | 0.695 |
| sICH (n (%)) | 2 (2.1) | 0 (0.0) | 2 (3.6) | 0.507 |
| Parenchymal hematoma (PH 2) | 1 (1.0) | 0 (0.0) | 1 (1.8) | 1.000 |
| Death by day 7 (n (%)) | 5 (5.1) | 1 (2.4) | 4 (7.0) | 0.393 |
rt-PA Alteplase, TNK Tenecteplase, (s)ICH (symptomatic) intracerebral hemorrhage, EVT Endovascular thrombectomy
Numbers written in bold indicate statistically significant group comparisons