Alignment (CLUSTAL X [see Materials and Methods]) of LasX with related sequences from Streptococcus gordonii (Rgg-Sg [42, 43]), Streptococcus oralis (Rgg-So [8]), Streptococcus pyogenes (RopB [4, 19]), Streptococcus mutans (MutR-II and MutR-III [25, 26]), and Lactococcus lactis (GadR [33]). Positions where at least four of the sequences have identical residues are highlighted (black boxes). Positions with nonidentical but similar residues are indicated with shaded boxes, and invariant positions are marked by asterisks.