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. 2025 Dec 3;15:43077. doi: 10.1038/s41598-025-27058-x

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© The Author(s) 2025

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Fig. 5 — Distribution of differentially methylated cytosine (DMC) residues in candidate genes (August compared with June). (A). Venn diagrams indicating the contexts of differentially methylated regions of candidate hypomethylated DEGs. (B). Average methylation site scores from three replicates across methylation contexts and time points in the specified genomic region. The top six panels represent scores (ranging from 0 to 100) for the three methylation contexts (CG, CHG, and CHH) in June (Jun) and August (Aug). The bottom panel illustrates the genomic features in the region, with exons depicted as rectangles and arrows depicting the direction of transcription. (C). DMC residues in CG context in a 5 kb region upstream from the translation start site, plotted as differential between average Aug and Jun methylation percentages. The distance from the translation start site in base pairs is given below. D. Expression (FPKMs ± SE of three biological replicates) of candidate genes.