Table 2.
Univariable and multivariable analysis of risk factors associated to all-cause 30-day mortality in the derivation cohort, with the deduced score points for each risk factor
| Variable | Crude analysis | Adjusted analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| No. deceased (%) [n = 135] | No. alive (%) [n = 1504] | OR (95% CI) | P value | β regression coefficient | OR (95% CI) | P value | Score points | |
| Age > 55 years | 120 (89.9) | 1237 (82.2) | 2.60 (1.30–5.19) | 0.005 | 0.74 | 2.10 (1.01–4.36) | 0.048 | 3 |
| Male sex | 82 (60.7) | 735 (48.9) | 1.66 (1.15–2.40) | 0.006 | ||||
| Dementia | 26 (19.3) | 145 (9.6) | 2.24 (1.41–3.54) | < 0.001 | 0.73 | 2.08 (1.24–3.50) | 0.006 | 3 |
| Myocardial infarction | 14 (10.4) | 110 (7.3) | 1.47 (0.82–2.64) | 0.198 | ||||
| Liver disease | 20 (14.8) | 90 (6.0) | 2.73 (1.62–4.60) | < 0.001 | 0.59 | 1.81 (0.99–3.28) | 0.052 | 2 |
| Neutrophils < 500 cells/mm3 | 7 (5.2) | 37 (2.5) | 2.17 (0.95–4.96) | 0.061 | ||||
| Central venous catheter | 20 (14.8) | 115 (7.6) | 2.10 (1.13–3.50) | 0.004 | ||||
| Urinary catheter | 22 (16.3) | 182 (12.1) | 1.41 (0.87–2.29) | 0.157 | ||||
| Mechanical ventilation | 5 (3.7) | 24 (1.6) | 2.37 (0.89–6.32) | 0.084 | ||||
| Health-care acquisition | 93 (68.9) | 679 (45.1) | 2.69 (1.84–3.93) | < 0.001 | 0.83 | 2.29 (1.52–3.44) | < 0.001 | 3 |
| Pitt score > 3 | 51 (37.8) | 164 (10.9) | 5.08 (3.46–7.48) | < 0.001 | 1.28 | 3.59 (2.30–5.61) | < 0.001 | 5 |
| SOFA score ≥ 2 | 105 (77.8) | 758 (50.4) | 3.44 (2.27–5.23) | < 0.001 | 0.51 | 1.66 (1.04–2.64) | 0.033 | 2 |
| Urinary source | 46 (34.1) | 927 (61.6) | 0.32 (0.22–0.47) | < 0.001 | -1.00 | 0.37 (0.24–0.56) | < 0.001 | -4 |
| ESBL production | 24 (17.8) | 191 (12.7) | 1.49 (0.93–2.37) | 0.094 | ||||
| Previous antimicrobials | 50 (37.0) | 380 (25.3) | 1.74 (1.20–2.51) | 0.003 | ||||
No Number, n Number of patients, OR Odds Ratio, CI Confidence Interval, SOFA Sequential Organ Failure Assessment, ESBL Extended-spectrum β-lactamases