Table 1.
The key experimental findings supporting CNS-mediated regulation of peripheral organs.
| Modeling method | Animal | Intervention | Outcome | Reference |
|---|---|---|---|---|
| CLP | Mouse | Inhibit the apoptosis of cholinergic neurons | Reduce lung injury | (9) |
| LPS | Mouse | Specifically activate α7nAChR (GTS-21) | Reduce kidney damage | (74) |
| LPS | Mouse | Specifically activate α7nAChR(GTS-21) | Reduce myocardial injury | (75) |
| CLP | Mouse | Specifically activate α7nAChR(GTS-21) | Reduce liver damage | (76) |
| CLP | Rat | Inhibit sympathetic activation | Reduce myocardial injury | (79) |
| Microbial peritonitis | Rat | Promote sympathetic activation | Impair respiratory function | (8) |
| LPS | Rat | Inhibit sympathetic activation | Reduce myocardial injury | (81) |
| CLP | Mouse | Inhibit necroptosis of GABAergic neurons | Reduce myocardial injury | (80) |
| CLP | Mouse | β-glucan-activated training immunity | Reduce liver and lung damage | (103) |