Skip to main content
. 2025 Nov 21;13:1684096. doi: 10.3389/fbioe.2025.1684096

FIGURE 1.

Three pie charts labeled A, B, and C. Chart A shows hemophilia and bleeding disorder distribution: Hemophilia A (48.5%), von Willebrand disease (24.7%), other bleeding diseases (15.1%), Hemophilia B (9.9%), and unknown (1.8%). Chart B details genetic mutation types: Intron 22 inversion (46%), small deletions/insertions (16%), missense (15%), nonsense (10%), unknown (5%), with others less than 5%. Chart C focuses on mutation frequencies for another genetic context: Missense (68%), nonsense (14%), splice (6%), and other mutations under 5%.

Proportional distributions pertaining to bleeding disorders and genetic variations associated with hemophilia. (A) Proportional distributions of prevalent bleeding disorders. Hemophilia A is deemed the most widespread coagulation disorder, noted for its nearly 50% prevalence among diverse bleeding disorders. (B) Hemophilia A‒associated genetic variations. The predominant instances of hemophilia A are linked to the inversion of intron 22 within the FVIII gene. (C) Hemophilia B‒associated genetic variations. Missense mutations within the FIX gene account for 68% of hemophilia instances.