Table 3.

Multivariate analyses (logistic regressions) of factors associated with ≥ 1 episode of PHNH during the 14-day period

Characteristic	Crude analyses			Adjusted for age and sex			Multiadjusteda
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
Sex (man)	1.19	0.87–1.62	0.268	1.14	0.84–1.56	0.387	1.17	0.85–1.62	0.330
Age (years)	0.98	0.97–0.99	< 0.001	0.98	0.97–0.99	< 0.001	0.98	0.97–0.99	0.017
LADA (yes)b	0.41	0.25–0.67	< 0.001	0.54	0.31–0.92	0.026	0.48	0.27–0.84	0.011
Total daily dose of insulin (IU/kg/day)	1.33	0.75–2.35	0.325	1.22	0.68–2.18	0.496	1.20	0.67–2.17	0.529

The multivariate logistic regression models included 755 cases, except those including the total daily dose of insulin, which included 735 cases

^aAdjusted for sex, age, LADA diagnosis, and total daily dose of insulin

^bSubtype of antibody-positive type 1 diabetes that is defined as adult-onset diabetes (> 30 years at diagnosis) with absence of insulin requirement for at least 6 months after diagnosis

OR, odds ratio. CI, confidence interval. IU, international units. LADA, latent autoimmune diabetes in adults