Table 1.
Comparison of published cases of VZV-vasculitis-related chorea and our patient showing diverse presentations, different diagnostic measures, methods of treatment and its effects. The table has been arranged chronologically, in order of publication date
| no. | Authors | Age, sex | Affected side | Time from VZV infection to hemichorea | Varicella vaccination status | Other clinical manifestations | Lesion location (MRI) | Affected vessels (MRA) | Side of described lesions | Laboratory findings - serum | Laboratory findings - CSF | Treatment | Clinical recovery time |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Klaus P Hammann et al. [15] | 20, F | R | 2 weeks | not available (N/A) |
myoclonic-like movements of arm and face paraesthesiae of fingers motor aphasia pyramidal syndrome |
N/A | N/A | N/A | (+) anti-VZV IgG | low protein content | carbamazepine | N/A |
| 2 | Silerstein et al.[16] | 6 | R | 2–3 months | N/A |
facial weakness hemiparesis |
globus pallidus caudate nucleus frontal lobe |
ICA ACA (A1) MCA (M1) |
L | (-) anti-VZV IgG | 9 white blood cells/mm3 | glucocorticoids | N/A |
| 3 | Miravet et al.[17] | 4 | N/A | N/A | N/A | transient hemifacial weakness |
basal ganglia white matter |
MCA | N/A | N/A | N/A | N/A | N/A |
| 4 | Miravet et al.[17] | 5 | L | N/A | N/A | hemiparesis | basal ganglia |
MCA ACA |
N/A | N/A | N/A | N/A | N/A |
| 5 | Buompadre et al.[18] | 4, F | N/A | N/A | N/A | hemiparesis |
lentiform nucleus caudate nucleus internal capsule |
MCA (M1) | N/A | N/A | N/A | N/A | N/A |
| 6 | Bartolini et al.[19] | 3, M | R | 15 days | N/A | none |
caudate nucleus lenticular nucleus |
MCA | L |
(+) IgG and IgM Ab against VZV (+) anti-protein S IgG and IgM antibodies |
N/A | ASA | N/A |
| 7 | Bartolini et al.[19] | 4, F | R | 7 months | N/A | none |
caudate nucleus lenticular nucleus internal capsule |
ACA (A1) MCA (M1) |
L + R |
(+) IgG Ab against VZV (-) IgM Ab against VZV |
N/A |
ASA valproic acid |
N/A |
| 8 | Bauder et al.[20] | 6,F | N/A | N/A | N/A | headache | N/A |
MCA PCA |
N/A | N/A | (+) VZV-DNA PCR |
acyclovir glucocorticoids |
N/A |
| 9 | Hackenberg et al.[21] | 4, M | N/A | N/A | N/A |
gait disorder dysphasia facial weakness mood disorder |
putamen |
ICA MCA ACA |
R | N/A | (-) VZV-DNA PCR |
acyclovir ASA glucocorticoids cyclophosphamide |
N/A |
| 10 | Bulder et al. [22] | 2, M | R | 2 months | N/A | none |
caudate nucleus putamen |
ICA ACA MCA (M1-M3) |
L | N/A | (-) VZV-DNA PCR | ASA | 1 month |
| 11 | Bulder et al. [22] | 3, F | L | 7 months | N/A | none |
caudate nucleus putamen |
MCA ACA |
R | N/A | N/A | ASA | 3 weeks |
| 12 | Spagnoli et al. [23] | 5, F | L | 5 months | unvaccinated |
trigeminal autonomic pain vomiting hemifacial grimaces lingual dyskinesias hypotonia hyposthenia exaggerated knee reflex |
lentiform nucleus internal capsule caudate nucleus |
ACA (A1) | R | (+) IgG Ab against VZV | N/A |
acyclovir ASA valproic acid |
N/A |
| 13 | Davico et al.[24] | 3, M | R | 6 months | N/A | none |
lentiform nucleus internal capsule |
none | L | (+) anti-VZV IgG | N/A |
ASA prednisone haloperidol |
3 weeks |
| 14 | Davico et al.[24] | 3, M | L | 4 months | N/A | none |
thalamus internal capsule |
ICA MCA |
R | (+) anti-VZV IgG | N/A |
ASA prednisone haloperidol |
3 weeks |
| 15 | Helmuth et al.[25] | 4, M | R | 8 months | N/A | hemiparesis | basal ganglia | none | L | N/A |
(+) VZV-DNA PCR (+) IgG Ab against VZV |
acyclovir ASA glucocorticoids |
N/A |
| 16 | Helmuth et al.[25] | 5, M | R | 6 months | N/A | dysarthria | temporal lobe | ICA | L | N/A |
(+) VZV-DNA PCR (+) IgG Ab against VZV |
acyclovir ASA glucocorticoids |
N/A |
| 17 | Helmuth et al.[25] | 5, M | L | 4 months | N/A | hemiparesis | white matter |
MCA ACA ICA |
R | N/A |
(+) VZV-DNA PCR (-) IgG Ab against VZV |
acyclovir ASA |
N/A |
| 18 | Elbishari et al.[26] | 1, M | N/A | 5 months | N/A |
upper extremity monoparesis intermittent ataxia |
globus pallidus |
MCA ACA |
L | N/A | (-) VZV-DNA PCR | N/A | N/A |
| 19 | Bertamino et al.[27] | 6, F | R | 7 months | unvaccinated | none | thalamus | none | L | (+) IgG Ab against VZV |
(+) IgG Ab against VZV (-) VZV-DNA PCR |
acyclovir ASA methylprednisolone |
N/A |
| 20 | O’Reilly et al. [28] | 1, M | N/A | 5 months | unvaccinated |
upper extremity monoparesis ataxia |
globus pallidus |
MCA ACA |
L | N/A | (+) VZV-DNA PCR |
acyclovir ASA methylprednisolone |
N/A |
| 21 | Bertanimo et al. [29] | 5, F | N/A | 9 months | unvaccinated | none | basal ganglia | none | N/A | N/A |
(+) IgG Ab against VZV (-) VZV-DNA PCR low protein content |
acyclovir ASA glucocorticoids |
N/A |
| 22 | Bertanimo et al. [29] | 4, M | N/A | 8 months | unvaccinated | none |
frontal lobe basal ganglia |
ICA MCA (M1) ACA (A1) |
R | N/A | (+) VZV-DNA PCR |
acyclovir ASA prednisone |
N/A |
| 23 | Schwidetzky et al. [30] | 6,F | L | 4 months | N/A | hemiparesis | N/A | MCA (M1) | R | N/A |
(+) VZV-DNA PCR (+) IgG Ab against VZV |
acyclovir methylprednisolone |
N/A |
| 24 | Our patient | 8, M | R | 6 months | Unvaccinated |
headaches transient facial weakness slurred speech tongue deviation |
putamen internal capsule subcortical white matter |
none | L |
(+) IgG Ab against VZV marginally negative IgM Ab against VZV |
(+) VZV-DNA PCR |
acyclovir ASA glucocorticoids |
2 weeks |