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. 2025 Nov 21;16:1688090. doi: 10.3389/fimmu.2025.1688090

Figure 2.

Five line graphs labeled A to E show cell count per microliter over time in days, with superimposed dashed lines representing coverage percentage. Graphs A to C and E show fluctuations in cell count with varying degrees before stabilizing, while graph D shows an initial sharp drop and a gradual stabilization. Coverage percentages in all graphs decrease over time. Graph A is blue, B is red, C is pink, D is purple, and E is orange.

Longitudinal kinetics of circulating lymphocyte subsets over time. (A–E) Smoothed (LOWESS, frac=0.15) counts for five lymphocyte subsets from −3 days to 180 days. The colored thick line in each panel tracks the subset’s mean trend; the thin dark-gray dashed line (right axis) reports the actual cohort coverage. Left y-axes display absolute cell counts (cells µL−¹); right y-axes display coverage percentage. (A) CD3+ T cells; (B) CD3+CD4+ T cells; (C) CD3+CD8+ T cells; (D) CD19+ naive B cells; (E) CD16+CD56+ natural killer cells. Legend (common to all panels): –Colored thick line = LOWESS trend for the indicated lymphocyte subset. –Gray thin dashed line = treatment coverage percentage (%). –Vertical dotted lines at 0, 90, and 180 days = reference time points. d = days.