Table 1.

Demographics of the study participants.

Clinical severity					5	4	3	2	1	5 cDM - Severe	4 cDM - Mod	3 Moderate adult		2 Mild adult		1 Normal
	Condition	Age	Sex	CTG Repeats	Prox - Mod Severe	Distal + Proximal	Only distal	Min - Myotonia	Normal	Not independent	Independent	With hypersomnia	No hypersomnia	With hypersomnia	No hypersomnia
Subject 1	DM1	25	F	500			X					X
Subject 2	DM1	54	F	75				X							X
Subject 3	DM1	44	F	542			X					X
Subject 4	DM1	42	F	129			X									X
Subject 5	DM1	32	F	368			x							x
Subject 6	DM1	32	F	250–350				X								X
Subject 7	DM1	26	F	536			X							X
Subject 8	DM1	31	M	DMPK expansion		X										X
Subject 9	DM1	26	F	DMPK expansion			X							X
Subject 10	DM1	54	F	714	X									X
Subject 11	DM1	41	F	1,005			X							X
Subject 12	CTL	62	M
Subject 13	CTL	33	F
Subject 14	CTL	55	M
Subject 15	CTL	42	M
Subject 16	CTL	30	M

DM1, Myotonic Dystrophy Type 1; Y, Years; CTG, cytosine, thymine, and guanine.

CTG repeat sizes were obtained from clinical genetic testing reports when available. Precise repeat counts were not uniformly available for all participants, precluding correlation analyses between repeat length and proteomic findings. One participant had documentation of DMPK expansion without specific repeat quantification.