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. 2025 Oct 21;69(12):e00931-25. doi: 10.1128/aac.00931-25

Fig 1.

Diagram of the cycloserine pharmacokinetic model showing delayed oral absorption through transit compartments to the central compartment with linear elimination, and distribution to lumbar CSF defined by partition coefficient and equilibration half-life.

Schematic representation of the cycloserine final model. Schematic representation of the final cycloserine model. Ktr is the first-order rate constant for drug passage through transit compartments. t1/2Plasma-CSF is the equilibration half-life between plasma and CSF, which describes how soon the change in plasma is reflected in the CSF. PPCCSF-Plasma is the pseudo-partition coefficient, which represents the relative drug exposure in CSF compared to plasma at steady state.