Fig 4.
Schematic representation of the clofazimine final model. Schematic representation of the final clofazimine model. Ktr is the first-order rate constant for drug passage through transit compartments. Q and Q2 represent the intercompartmental clearances between the central and the two peripheral plasma compartments. t1/2Plasma-CSF is the equilibration half-life between plasma and CSF, which describes how soon the change in plasma is reflected in the CSF. PPCCSF-Plasma is the pseudo-partition coefficient which represents the relative drug exposure in CSF compared to plasma at steady state.