Skip to main content
. 2025 Nov 30;26(23):11615. doi: 10.3390/ijms262311615
PD Parkinson’s disease
cfDNA Cell-free DNA
cf-ntDNA Nuclear derived cell-free DNA
cf-mtDNA Mitochondrially derived cell-free DNA
CSF Cerebrospinal fluid
LBs Lewy bodies
SN Substantia nigra
LRRK2 Leucine rich repeat kinase 2
CAD Caspase-activated DNase
dsDNA Double-stranded DNA
NETs Neutrophil extracellular traps
ROS Reactive oxygen species
AD Alzheimer’s disease
RNA Ribonucleic acids
ASO Antisense oligonucleotide
EVs Extracellular vesicle
DAMPs Damage-Associated Molecular Patterns
tRNA Transfer RNA
rRNA Ribosomal RNA
ER Endoplasmic reticulum
FIS1 Mitochondrial fission protein 1
DRP1 Dynamic-related protein 1
MFN1/2 Mitofusion proteins 1 and 2
LIR LC3 interacting region
PINK1 PTEN-induced putative kinase 1
PTEN Phosphatase and tensin homologue deleted on chromosome 10
TOM Translocase of the outer membrane
TIM Translocase of the inner membrane
PARL Presenilin-associated rhomboid-like protein
OMM Outer mitochondrial membrane
OPTN Optineurin
NDP52 Nuclear dot protein 52
CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2
MDVs Mitochondrially derived vesicles
cGAS Cyclic GMP/AMP synthase
cGAMP Cyclic guanosine monophosphate–adenosine monophosphate
STING Stimulator of interferon genes
TCA Tricarboxylic acid cycle
PRRs Pattern recognition receptors
TLRs Toll-like receptors
NOD Nucleotide-binding oligomerization domain
NLRs Nucleotide-binding oligomerization domain like receptors
HD Huntington’s disease
ALS Amyotrophic lateral sclerosis
MS Multiple sclerosis
IRF3 Interferon regulatory factor 3
IKK IkappaB kinase
TBK1 TANK-binding kinase 1
qPCR Quantitatively polymerase chain reaction
PCR Polymerase chain reaction
NGS Next Generation Sequencing
TNF Tumor necrosis factor
IFNɣ Interferon gamma
IL-6 Interleukin 6