Previous severe cardiorespiratory illness – acute myocardial infarction, chronic obstructive pulmonary disease, or stroke |
Late-stage vascular disease involving aorta |
Age > 70 years with limited physiological reserve in one or more vital organs |
Extensive surgery for carcinoma (e.g. oesophagectomy, gastrectomy cystectomy) |
Acute abdominal catastrophe with haemodynamic instability (e.g. peritonitis, perforated viscus, pancreatitis) |
Acute massive blood loss > 8 units |
Septicaemia |
Positive blood culture or septic focus |
Respiratory failure: PaO2 < 8.0 kPa on FIO2 > 0.4 or mechanical ventilation > 48 hours |
Acute renal failure: urea > 20 mmol/l or creatinine > 260 mmol/l |