Table 4.

Change in serum biological parameters from admission to day 4 of treatment

Parameter	Day 0	Day 1	Day 2	Day 3	Day 4
Leucocyte (109/l)	14.2 (10–19)	14 (11.8–18)	13.5 (11–17)	10.5 (8.5–12)	10.2 (8–13)
Fibrinogen (g/l)	4.8 (4–6.4)	6.2 (5–7.5)	6.2 (5.6–8.2)	6.4 (5.8–8.4)	6.3 (5–8)
C-reactive protein (mg/l)	120 (48–241)	221 (141–299)	156 (121–240)	93 (67–170)	82 (43–130)
Procalcitonin ng/ml)	4.5 (2.8–10.8)	3.8 (1.5–10.7)	2* (0.9–5)	1.4 (0.4–3)	0.7 (0.4–1.3)

Values are expressed as median (interquartile range). *P < 0.0001 versus day 0.