Table 2.
Individual IA treatment characteristics.
| No. | Diagnosis | Parameters | IA sessions | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |||
| 1 | AE | Cycles | 6 | 6 | 6 | 6 | / | / | / | / | / | / |
| Total circulation (ml) | 3,600 | 3,600 | 3,600 | 3,600 | / | / | / | / | / | / | ||
| ISIs (days) | - | 1 | 0 | 2 | / | / | / | / | / | / | ||
| Pre-IgG (g/L) | 5.69 | 8.11 | 5.43 | 2.73 | / | / | / | / | / | / | ||
| Post-IgG (g/L) | 1.01 | 1.25 | 0.72 | 0.4 | / | / | / | / | / | / | ||
| 2 | AE | Cycles | 8 | 8 | 5 | 5 | 5 | 5 | 6 | / | / | / |
| Total circulation (ml) | 4,800 | 4,800 | 3,000 | 3,000 | 3,000 | 3,000 | 3,600 | / | / | / | ||
| ISIs (days) | - | 0 | 25 | 1 | 3 | 1 | 1 | / | / | / | ||
| Pre-IgG (g/L) | 17.1 | 7.43 | 8.78 | 7.8 | 14.5 | 17.4 | 14.9 | / | / | / | ||
| Post-IgG (g/L) | 7.33 | 2.14 | 7.11 | 5.93 | 9.64 | 10.6 | 9.44 | / | / | / | ||
| 3 | AE | Cycles | 8 | 8 | 8 | / | / | / | / | / | / | / |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | / | / | / | / | / | / | / | ||
| ISIs (days) | 0 | 0 | 0 | / | / | / | / | / | / | / | ||
| Pre-IgG (g/L) | 4.6 | 3.33 | 3.9 | / | / | / | / | / | / | / | ||
| Post-IgG (g/L) | 1.65 | 1.14 | 1.29 | / | / | / | / | / | / | / | ||
| 4 | AE | Cycles | 10 | 10 | 10 | 8 | 8 | 8 | / | / | / | / |
| Total circulation (ml) | 6,000 | 6,000 | 6,000 | 4,800 | 4,800 | 4,800 | / | / | / | / | ||
| ISIs (days) | - | 0 | 12 | 0 | 2 | 1 | / | / | / | / | ||
| Pre-IgG (g/L) | 6.06 | 4.16 | 11.6 | 7.33 | 6.39 | 8.07 | / | / | / | / | ||
| Post-IgG (g/L) | 1.19 | 1.37 | 5.84 | 2.82 | 6.52 | 7.23 | / | / | / | / | ||
| 5 | AE | Cycles | 8 | 8 | 8 | / | / | / | / | / | / | / |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | / | / | / | / | / | / | / | ||
| ISIs (days) | - | 0 | 0 | / | / | / | / | / | / | / | ||
| Pre-IgG (g/L) | 7.37 | DNT | 3.23 | / | / | / | / | / | / | / | ||
| Post-IgG (g/L) | 3.56 | DNT | 1.01 | / | / | / | / | / | / | / | ||
| 6 | GBS | Cycles | 10 | 8 | 8 | 8 | 8 | 8 | 10 | 10 | 10 | 8 |
| Total circulation (ml) | 6,000 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 6,000 | 6,000 | 6,000 | 4,800 | ||
| ISIs (days) | 0 | 4 | 1 | 1 | 3 | 0 | 9 | 1 | 2 | 1 | ||
| Pre-IgG (g/L) | 10 | 7.46 | 5.11 | 7.66 | DNT | 6.06 | 11.5 | 8.58 | 7.73 | 9.78 | ||
| Post-IgG (g/L) | 2.24 | 1.82 | 4.14 | DNT | 1.95 | 1.75 | 5.7 | 4.86 | 4.31 | 6.64 | ||
| 7 | GBS | Cycles | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | ||
| ISIs (days) | - | 0 | 0 | 2 | 1 | 1 | 2 | 1 | 1 | 1 | ||
| Pre-IgG (g/L) | 16.8 | 11.2 | 6.48 | 6.76 | 4.32 | 2.49 | 3.23 | 3.37 | 3.23 | 3.04 | ||
| Post-IgG (g/L) | 10.3 | DNT | 6.82 | 3.12 | 1.89 | 1.28 | 1.52 | 1.29 | 1.22 | 1.18 | ||
| 8 | GBS | Cycles | 8 | 8 | 8 | 8 | 5 | 8 | 8 | / | / | / |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | 4,800 | 3,000 | 4,800 | 4,800 | / | / | / | ||
| ISIs (days) | - | 0 | 0 | 2 | 1 | 2 | 0 | / | / | / | ||
| Pre-IgG (g/L) | 17.3 | 8.09 | 10.04 | 5.87 | 7.43 | DNT | 8.21 | / | / | / | ||
| Post-IgG (g/L) | 8.09 | DNT | 4.22 | 1.79 | 3.16 | DNT | 3.91 | / | / | / | ||
| 9 | GBS | Cycles | 8 | 8 | / | / | / | / | / | / | / | / |
| Total circulation (ml) | 4,800 | 4,800 | / | / | / | / | / | / | / | / | ||
| ISIs (days) | - | 0 | / | / | / | / | / | / | / | / | ||
| Pre-IgG (g/L) | 17.2 | 6.01 | / | / | / | / | / | / | / | / | ||
| Post-IgG (g/L) | 6.01 | 0.95 | / | / | / | / | / | / | / | / | ||
| 10 | CIPD | Cycles | N/A | 10 | 10 | 10 | 10 | / | / | / | / | / |
| Total circulation (ml) | N/A | 6,000 | 6,000 | 6,000 | 6,000 | / | / | / | / | / | ||
| ISIs (days) | N/A | 0 | 30 | 0 | 0 | / | / | / | / | / | ||
| Pre-IgG (g/L) | 25.3 | 10.07 | 16.9 | 14.6 | 17.3 | / | / | / | / | / | ||
| Post-IgG (g/L) | 18 | 6.98 | DNT | DNT | DNT | / | / | / | / | / | ||
| 11 | NMOSDs | Cycles | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | 4,800 | ||
| ISIs (days) | - | 0 | 1 | 1 | 1 | 4 | 2 | 0 | 2 | 0 | ||
| Pre-IgG (g/L) | 16.7 | 17.8 | 10.6 | 7.8 | 10.4 | 14.8 | 12.5 | 6.82 | 13.9 | 11.1 | ||
| Post-IgG (g/L) | 7.84 | 8.53 | DNT | 2.24 | 3.9 | 8.41 | 6.28 | 5.53 | 6.29 | 6.24 | ||
| 12 | NMOSDs | Cycles | 8 | 8 | 8 | 4 | 8 | 4 | 8 | 10 | 8 | 10 |
| Total circulation (ml) | 4,800 | 4,800 | 4,800 | 2,400 | 4,800 | 2,400 | 4,800 | 6,000 | 4,800 | 6,000 | ||
| ISIs (days) | - | 0 | 0 | 0 | 2 | 0 | 3 | 3 | 2 | 3 | ||
| Pre-IgG (g/L) | 29.2 | 14.3 | 6.83 | 3.46 | 8.56 | 3.68 | 11.5 | 9.51 | 6.27 | 8.47 | ||
| Post-IgG (g/L) | 13.6 | 5.99 | 1.99 | 1.72 | 1.9 | 1.82 | 4.25 | 1.94 | 1.59 | 2.61 | ||
| 13 | NMOSDs | Cycles | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | / |
| Total circulation (ml) | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | 3,000 | N/A | / | ||
| ISIs (days) | - | 0 | 2 | 2 | 2 | 1 | 1 | 11 | 1 | / | ||
| Pre-IgG (g/L) | 20.5 | 17.9 | 11.9 | 17.1 | 13.7 | 9.84 | 16.1 | 12.5 | 14.1 | / | ||
| Post-IgG (g/L) | 12.1 | 13.6 | 8.22 | DNT | 8.28 | 5.52 | 8.45 | 9.35 | 8.08 | / | ||
“N/A” = not applicable; “DNT” = did not test; pre/post-IgG = immunoglobulin G levels before and after each IA session; ISIs = inter-session intervals (days between each IA session); each IA session consisted of multiple cycles (the number of cycles and total circulation volume varied based on individual patient tolerance); disease abbreviations are defined in the footnote of Table 1.