Table 3. Effect of Awake Prone Positioning Estimated by Bayesian Analysis According to a Noninformative Prior Distribution About Primary and Secondary Outcomes in the Per-Protocol Population.
| Outcome | Standard care group, No. (%) (n = 177) | APP group, No. (%) (n = 179) | Mean estimated difference (95% CrI) | Mean OR (95% CrI) | Posterior median absolute RRR (95% CrI) | Posterior probability of RRR, % | Posterior probability of difference reduction, % |
|---|---|---|---|---|---|---|---|
| Primary | |||||||
| Intubation and/or death within 28 d of enrollment | 60 (34) | 40 (22) | NA | 0.58 (0.35 to 0.89) | 0.12 (0.02 to 0.21) | 99.3 | NA |
| Intubation | 53 (30) | 37 (21) | NA | 0.63 (0.37 to 0.98) | 0.09 (0.01 to 0.18) | 97.9 | NA |
| Death | 26 (15) | 16 (9) | NA | 0.60 (0.29 to 1.09) | 0.06 (0.00 to 0.12) | 95.6 | NA |
| Secondary | |||||||
| Days alive and free from mechanical ventilation within 28 d of enrollment, median (IQR) | 28 (23.5 to 28) | 28 (28 to 28) | 0.77 (−1.07 to 2.61) | NA | NA | NA | 79.4 |
| Days alive outside the ICU within 28 d of enrollment, median (IQR) | 21 (0 to 26) | 22 (9.5 to 25) | 1.40 (−0.85 to 3.64) | NA | NA | NA | 88.9 |
| Days alive outside the hospital within 28 d of enrollment, median (IQR) | 15 (0 to 20) | 16 (0 to 20) | 1.40 (−0.57 to 3.36) | NA | NA | NA | 91.9 |
| ICU admission | 13 (23)a | 12 (26)a | NA | 0.99 (0.40 to 2.06) | 0.02 (0.00 to 0.06) | 59.4 | NA |
Abbreviations: APP, awake prone positioning; CrI, credible interval; ICU, intensive care unit; NA, not applicable; OR, odds ratio; RRR, relative risk reduction.
a
Fifty-six patients in the standard care group and 47 patients in the APP group were not admitted into the ICU at the time of study enrollment.