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. 2025 Nov 28;6:1706912. doi: 10.3389/fresc.2025.1706912

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© 2025 Ladell, Golden, Oliemans, Walls, Manocha and Fletcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar chart comparing domain scores for hEDS and control groups across five categories: physical function, physical role limitations, body pain, general health, and energy/fatigue. Control scores are higher in all categories, with significant differences noted. — Mean ± SD FSS for HSD/hEDS (grey) and CON (black). * indicates significant group differences (p < 0.05), ** indicates significant group differences (p < 0.001).