. 2002 Jan;46(1):89–94. doi: 10.1128/AAC.46.1.89-94.2002

TABLE 1.

Frequencies of mutations associated with resistance to abacavir in clinical isolates (n = 307), ranked with increasing resistance to abacavir

Fold reduced susceptibility to abacavir^a	Frequency (%) of mutations associated with resistance to abacavir (6, 17, 23)					No. of samples
Fold reduced susceptibility to abacavir^a	K65R	L74V	Y115F	NRTI MDR^b	M184V/I	No. of samples
<2.5	0	3.1	0	0	11.5	96
2.5–5.5	0	3.8	1.3	1.3	43.8	80
>5.5	1.5	20.6	0	9.9	71.0	131

Fold increase in the IC₅₀ of the respective recombinant virus compared to the IC₅₀ of the nonresistant reference virus NL4-3.

Amino acid insertions between codons 67 and 70 of the reverse transcriptase (14) or Q151M (plus A62V, S68G, V751, F77L, and F116Y) (24).