TABLE 1.

Antimicrobial activity of BMS-284756 compared to those of other antibiotics tested by reference methods (12) (E-test; AB Biodisk) against streptococci, staphylococci, and enterococci^a

Organism and antibiotic	No. of organisms tested	MIC (μg/ml)			% Susceptible
		MIC50	MIC90	Range
S. pneumoniae, penicillin susceptible	43
BMS-284756		0.12	0.12	0.03–4
Moxifloxacin		0.25	0.25	0.12–2	98
Gatifloxacin		0.25	0.5	0.12–1	100
Ciprofloxacin		2	4	0.25–16
Ceftriaxone		0.03	0.25	0.002–0.5	100
Imipenem		0.03	0.12	0.002–0.5	95
Piperacillin-tazobactam		0.03	1	0.03–2	79
Amoxicillin-clavulanic acid		0.03	0.25	0.03–0.5	100
S. pneumoniae, penicillin nonsusceptible	22
BMS-284756		0.06	0.12	0.06–0.12
Moxifloxacin		0.25	0.25	0.12–0.25	100
Gatifloxacin		0.25	0.5	0.12–4	95
Ciprofloxacin		2	4	0.5–>32
Ceftriaxone		1	2	0.25–4	14
Imipenem		0.25	0.5	0.25–1	0
Piperacillin-tazobactam		2	4	1–16	0
Amoxicillin-clavulanic acid		1	2	1–16	0
S. pyogenes	17
BMS-284756		0.12	0.25	0.06–0.25
Moxifloxacin		0.25	0.25	0.12–0.5	100
Gatifloxacin		0.25	0.5	0.25–1	100
Ciprofloxacin		0.5	1	0.25–4
Ceftriaxone		0.03	0.12	0.002–0.25	100
Imipenem		0.008	0.03	0.002–0.12	100
Piperacillin-tazobactam	0.06	0.12	0.03–1	88
Amoxicillin-clavulanic acid		0.03	0.03	0.03–0.25	100
S. agalactiae	15
BMS-284756		0.12	0.25	0.06–0.5
Moxifloxacin		0.25	0.25	0.25–0.5	100
Gatifloxacin		0.5	0.5	0.25–2	100
Ciprofloxacin		1	2	0.5–>32
Ceftriaxone		0.06	0.12	0.03–1	87
Imipenem		0.03	0.06	0.008–0.12	100
Piperacillin-tazobactam		0.25	0.25	0.12–0.5	33
Amoxicillin-clavulanic acid		0.06	0.06	0.03–0.25	100
Group G streptococci	10
BMS-284756		0.12	0.12	0.06–0.12
Moxifloxacin		0.25	0.25	0.12–0.25	100
Gatifloxacin		0.25	0.5	0.25–0.5	100
Ciprofloxacin		0.5	2	0.5–2
Ceftriaxone		0.015	0.06	0.004–0.06	100
Imipenem		0.008	0.03	0.002–0.03	100
Piperacillin-tazobactam		0.06	0.12	0.03–0.25	90
Amoxicillin-clavulanic acid		0.03	0.03	0.03–0.03	100
S. viridans	38
BMS-284756		0.12	0.25	0.06–0.25
Moxifloxacin		0.25	0.25	0.12–0.5	100
Gatifloxacin		0.25	0.5	0.06–0.5	100
Ciprofloxacin		2	4	0.25–8
Ceftriaxone		0.25	1	0.015–>32	87
Imipenem		0.12	0.25	0.03–2	100
Piperacillin-tazobactam		1	4	0.06–8	18
Amoxicillin-clavulanic acid		0.25	1	0.03–4	58
S. aureus, methicillin and penicillin sensitive	60
BMS-284756		0.06	0.06	0.015–0.06
Moxifloxacin		0.12	0.25	0.06–0.5	100
Gatifloxacin		0.12	0.25	0.06–0.25	100
Ciprofloxacin		0.25	0.5	0.12–0.5	100
Ceftriaxone		4	4	0.03–4	100
Imipenem		0.06	0.06	0.008–0.06	100
Piperacillin-tazobactam		2	2	0.06–4	100
Amoxicillin-clavulanic acid		1	1	0.03–1	100
S. aureus, methicillin sensitive, penicillin resistant	20
BMS-284756		0.06	0.06	0.008–2
Moxifloxacin		0.12	0.25	0.06–2	100
Gatifloxacin		0.12	0.25	0.06–4	95
Ciprofloxacin		0.25	0.5	0.25–>32	95
Ceftriaxone		4	4	4–>32	95
Imipenem		0.06	0.06	0.03–0.12	100
Piperacillin-tazobactam		2	2	1–4	100
Amoxicillin-clavulanic acid		1	1	0.5–2	100
S. aureus, methicillin resistant, ciprofloxacin sensitive	10
BMS-284756		0.03	0.12	0.03–0.12
Moxifloxacin		0.12	0.25	0.06–0.25	100
Gatifloxacin		0.12	0.25	0.12–0.25	100
Ciprofloxacin		0.5	1	0.25–1	100
Ceftriaxone		>32	>32	2–>32	20
Imipenem		0.5	4	0.03–>32	90
Piperacillin-tazobactam		8	64	1–>256	50
Amoxicillin-clavulanic acid		8	16	0.5–32	40
S. aureus, methicillin resistant, ciprofloxacin resistant	85
BMS-284756		2	4	0.12–16
Moxifloxacin		4	8	0.5–32	36
Gatifloxacin		8	16	0.5–>32	14
Ciprofloxacin		>32	>32	4–>32	0
Ceftriaxone		>32	>32	12–>32	0
Imipenem		16	>32	0.25–>32	36
Piperacillin-tazobactam		64	>256	2–>256	12
Amoxicillin-clavulanic acid		16	32	2–64	15
S. epidermidis, methicillin sensitive	20
BMS-284756		0.12	2	0.03–8
Moxifloxacin		0.12	1	0.06–4	95
Gatifloxacin		0.25	4	0.06–4	85
Ciprofloxacin		0.25	16	0.25–>32	85
Ceftriaxone		2	>32	0.5–>32	60
Imipenem		0.06	0.25	0.008–0.25	100
Piperacillin-tazobactam		0.5	2	0.03–2	100
Amoxicillin-clavulanic acid		0.25	4	0.03–4	100
S. epidermidis, methicillin resistant	25
BMS-284756		2	4	0.03–16
Moxifloxacin		4	8	0.12–16	44
Gatifloxacin		2	8	0.06–16	56
Ciprofloxacin		>32	>32	0.25–>32	28
Ceftriaxone		>32	>32	4–>32	12
Imipenem		4	>32	0.06–32	64
Piperacillin-tazobactam		2	64	0.06–>256	68
Amoxicillin-clavulanic acid		2	16	0.25–32	64
Coagulase-negative staphyloccoci, methicillin sensitive	37
BMS-284756		0.06	0.12	0.015–4
Moxifloxacin		0.12	0.25	0.06–4	97
Gatifloxacin		0.25	0.25	0.12–4	97
Ciprofloxacin		0.25	0.5	0.25–>32	95
Ceftriaxone		2	16	0.25–>32	86
Imipenem		0.06	0.12	0.008–1	100
Piperacillin-tazobactam		0.5	2	0.03–4	100
Amoxicillin-clavulanic acid		0.25	1	0.03–2	100
Coagulase-negative staphylococci, methicillin resistant	40
BMS-284756		0.12	4	0.03–8
Moxifloxacin		0.25	4	0.06–32	77
Gatifloxacin		0.25	4	0.12–>32	70
Ciprofloxacin		0.25	>32	0.25–>32	60
Ceftriaxone		>32	>32	0.5–>32	7
Imipenem		>32	>32	0.03–>32	37
Piperacillin-tazobactam		4	128	0.25–>256	82
Amoxicillin-clavulanic acid		4	16	0.25–64	57
E. faecalis	25
BMS-284756		0.25	0.5	0.12–4
Moxifloxacin		0.5	0.5	0.25–>32	96
Gatifloxacin		0.5	1	0.25–>32	96
Ciprofloxacin		2	2	1–>32	32
Ceftriaxone		>32	>32	>32	0
Imipenem		2	2	1–8	96
Piperacillin-tazobactam		4	4	2–8	100
Amoxicillin-clavulanic acid		1	1	0.5–1	100
E. faecium	25
BMS-284756		4	32	0.25–>32
Moxifloxacin		2	>32	0.12–>32	64
Gatifloxacin		2	>32	0.25–>32	64
Ciprofloxacin		4	>32	0.5–>32	4
Ceftriaxone		>32	>32	>32	0
Imipenem		>32	>32	1–>32	24
Piperacillin-tazobactam		>256	>256	0.5–>256	12
Amoxicillin-clavulanic acid		32	128	0.5–>256	36

^aBreakpoints approved by the National Committee for Clinical Laboratory Standards are currently not available for BMS-284756.