TABLE 1.

MIC and FICI results of the test isolates at 24 h

Isolate	MIC (μg/ml)a			FICI	Resultb
	Endpoint	AMB alone	CAS alonec
Aspergillus spp. (n = 14)
A. fumigatus (n = 4)
2-160	MIC-0	0.5	>16	0.5	S
	MEC	0.125	0.25	0.6	Ad
7099	MIC-0	0.25	>16	1.0	Ad
	MEC	0.125	0.25	0.7d	Ad
7100	MIC-0	0.25	>16	1.0	Ad
	MEC	0.125	0.25	0.7	Ad
2-103	MIC-0	0.25	>16	0.5	S
	MEC	0.06	0.25	1.2	I
A. flavus (n = 4)
1-74	MIC-0	0.5	>16	2.0	I
	MEC	0.5	>16	1.0	Ad
1-68	MIC-0	1	>16	1.0	Ad
	MEC	0.5	0.5	1.5	I
1-38	MIC-0	1	>16	2.1	I
	MEC	1	>16	0.5	S
1-42	MIC-0	1	>16	1.0	Ad
	MEC	0.5	>16	1.0	Ad
A. niger (n = 3)
1-44	MIC-0	0.125	1	1.1	I
	MEC	0.125	0.25	0.8	Ad
1-62	MIC-0	0.06	>16	2	I
	MEC	0.03	0.25	2.2d	I
1-63	MIC-0	0.06	>16	1.0	Ad
	MEC	0.03	0.25	1.2	I
A. terreus (n = 3)
1-58	MIC-0	1	>16	1.0	Ad
	MEC	0.5	0.25	0.4	S
1-79	MIC-0	0.125	>16	2.0	I
	MEC	0.06	0.25	2.6	I
1-50	MIC-0	2	>16	1.0	Ad
	MEC	1	0.25	1.3	I
Fusarium spp. (n = 6)
F. solani (n = 4)
S-1319	MIC-0	2	>16	2.1	I
	MEC	0.25	16	1.0	Ad
S-1382	MIC-0	0.5	>16	2.0	I
	MEC	0.25	16	0.5d	S
S-1237	MIC-0	2	>16	0.5	S
	MEC	1	16	0.5	S
S-1381	MIC-0	8	>16	0.6	Ad
	MEC	1	>16	2.1d	I
F. oxysporum (n = 2)
O-1895	MIC-0	2	>16	0.5	S
	MEC	1	16	NAe	NA
O-1739	MIC-0	2	>16	0.5	S
	MEC	1	16	0.5	S

^aAMB, amphotericin B; CAS, caspofungin; MEC: minimum effective concentration, equivalent to macroscopic MIC-2.

^bS, synergistic; Ad, additive; I, indifferent.

^cThe high off-scale MIC value, >16 μg/ml, was converted to the next highest concentration, 32 μg/ml, for calculation of FICI.

^dMEC is not available or is inconsistent; thus, MIC-1 (∼80% reduction in turbidity) is used for calculation of the FICI.

^eNA, not applicable; none of the concentrations of the drug produced turbidity equivalent to that endpoint.