TABLE 3.
Effects of polyamine analogs on mice infected with E. cuniculi
| Expt no. and mouse strain | Treatment (dose [mg/kg]) | No. of mice with ascites/no. of mice tested | No. of deaths/no. of mice tested | Cure rate (%) |
|---|---|---|---|---|
| Expt 1, BALB/c nu/nu | Control | 6/6 | 6/6a | |
| SL-11061 (BE-4-4-4-4) (10) | 1/6 | 0/6b | 100 | |
| Expt 2, BALB/c nu/nu | Control | 6/6 | 6/6c | |
| SL-11061 (10) | 5/5 | 1/5d | 80 | |
| Expt 3, C57BL/6J ΔCD8 | Control | 3/3 | 3/3e | |
| SL-11144 (2.5) | 0/3 | 0/3 | 100 | |
| Expt 4, C57BL/6J ΔCD8 | Control | 2/2 | 2/2e | |
| SL-11144 (1.25) | 0/2 | 0/2 | 100 | |
| SL-11061 (1.25) | 0/2 | 0/2 | 100 | |
| Expt 5, C57BL/6J ΔCD8 | Control | 2/2 | 2/2e | |
| SL-11158 (5) | 0/4 | 0/4 | 100 | |
| Expt 6, C57BL/6J ΔCD8 | Control | 5/5 | 5/5f | |
| SL-11093 (1.0) | 5/5 | 1/5d | 80 | |
| SL-11093 (5.0) | 0/5 | 0/5 | 100 |
a
All mice were dead by day 27.
b
No deaths during a 50-day observation period.
c
All mice were dead by day 49; cured animals were observed for 20 days after deaths of control mice.
d
All mice were dead by day 20.
e
All mice were dead by day 14.
f
All mice were dead by day 22. None of the treated mice had ascites, and there was no evidence of the organism by PCR analysis (27) or histologic staining tissues in cured mice.