FIG. 2.

Response of primary pulmonary aspergillosis in persistently neutropenic rabbits to antifungal therapy measured by survival, mean lung weight, mean pulmonary infarct score, and mean pulmonary tissue concentration of residual organisms (log CFU/gram) in untreated controls (n = 12) and rabbits treated with CAS (CAS1 [n = 12], CAS3 [n = 12], CAS6 [n = 12]) or AMB (1 mg/kg/day) (n = 6). Values are given as means ± SEMs (error bars). P values are indicated as follows (in comparison to untreated controls, calculated by using ANOVA with Bonferroni’s correction for multiple comparisons): *, P < 0.05; §, P < 0.01; ¶, P < 0.001. For the measure of survival, the values on the x axis are days following inoculation and the values on the y axis are probability of survival.