TABLE 1.
Survival of persistently neutropenic rabbits with primary pulmonary aspergillosis treated with different doses of CAS or AMB compared to that of untreated control rabbits
| Treatment group (n) | Survival (days)
|
P valueb | |||
|---|---|---|---|---|---|
| Mean ± SEM | Median | Range | 95% CIa | ||
| Control (12) | 6.92 ± 0.69 | 6.0 | 4–13 | 5.40–8.44 | |
| CAS (all doses) (36) | 10.03 ± 0.36 | 10.0 | 6–13 | 9.31–10.75 | <0.001 |
| CAS1 (12) | 10.42 ± 0.54 | 10.0 | 7–13 | 9.22–11.61 | <0.001 |
| CAS3 (12) | 10.17 ± 0.61 | 10.5 | 5–13 | 8.82–11.52 | <0.01 |
| CAS6 (12) | 9.50 ± 0.70 | 9.0 | 6–13 | 7.96–11.04 | <0.05 |
| AMB (6) | 8.83 ± 0.48 | 9.0 | 7–10 | 7.61–10.06 | >0.05 |
a
95% CI, 95% confidence interval.
b
P values comparing survival values for the treated group to those for the control group were calculated by using ANOVA with Bonferroni’s correction for multiple comparisons.