TABLE 1.
Comparison of baseline parameters in patients with AIDS and histoplasmosis treated with itraconazole versus fluconazolea
| Drug | Parameters (P)
|
||||||
|---|---|---|---|---|---|---|---|
| Karnofsky <60 (0.577) | CD4 count, median × 10a/ liter (0.456) | Antiretroviral use (0.006) | Prior amphotericin B (0.657) | Positive blood cultures (0.822) | Serum antigen, mean ± 1 SD (0.724) | Urine antigen, mean ± 1 SD (0.136) | |
| ACTG 120-itraconazole | 16/59 (27%) | 29; n = 53; range = 2–346 | 35/59 (59%) | 11/58 (19%) | 43/54 (80%) | 9.38 ± 5.89 (n = 33) | 9.72 ± 4.63 (n = 42) |
| ACTG 174-fluconazole | 11/49 (22%) | 25; n = 45; range = 1–108 | 16/49 (33%) | 11/49 (22%) | 35/45 (78%) | 8.88 ± 6.07 (n = 41) | 11.23 ± 4.69 (n = 44) |
a
Baseline values are taken from all patients enrolled in the study.