FIG. 5.

Effect of addition of 175 ng (0.88 μM) of unlabeled artemisinin on the partitioning of 0.88 μM [¹⁴C]artemisinin into both nonparasitized RBCs (A) and parasitized (7% parasitemia) RBCs (B). Triplicate samples with 33% hematocrit were prepared and incubated at 37°C for 2 h. The unlabeled artemisinin was added along with, 1 h prior to, and 1 h after the addition of [¹⁴C]artemisinin. The actual amount of drug partitioned was calculated, converted to percent drug partitioned, and plotted.