Table 2.
Comparison of Clinicopathological Features of NSMP and Non-NSMP Endometrial Cancer
| Clinicopathological Features | NSMP (n = 159) | Non-NSMP (n = 404) | P Values |
|---|---|---|---|
| Age (years) | |||
| <55, n (%) | 65(40.9%) | 158(39.1%) | 0.703 (χ2= 0.150) |
| ≥55, n (%) | 94(59.1%) | 246(60.9%) | |
| Reproductive history | |||
| No, n (%) | 8(5.0%) | 8(2.0%) | 0.085 (χ2= 3.847) |
| Yes, n (%) | 151(95.0%) | 396(98.0%) | |
| Menopause | |||
| No, n (%) | 55(34.6%) | 119(29.5%) | 0.267 (χ2= 1.244) |
| Yes, n (%) | 104(65.4%) | 281(69.6%) | |
| Histological type | |||
| Endometrioid carcinoma, n (%) | 151(95.0%) | 332(82.3%) | 0.012 (χ2= 14.073) |
| Serous carcinoma, n (%) | 1(0.6%) | 32(7.9%) | |
| Clear cell carcinoma, n (%) | 3(1.9%) | 8(2.0%) | |
| Squamous cell carcinoma, n (%) | 1(0.6%) | 1(0.2%) | |
| Mixed carcinoma, n (%) | 2(1.3%) | 10(2.5%) | |
| Others, n (%) | 1(0.6%) | 6(1.5%) | |
| Tumor differentiation | |||
| Well, n (%) | 43(27.0%) | 75(18.6%) | <0.001 (χ2= 16.457) |
| Moderate, n (%) | 103(64.8%) | 210(52.0%) | |
| Poor, n (%) | 9(5.7%) | 70(17.3%) | |
| Muscular infiltration | |||
| Endometrium, n (%) | 25(15.7%) | 59(14.6%) | 0.969 (χ2= 0.072) |
| <1/2 muscular layer, n (%) | 97(61.0%) | 215(53.2%) | |
| ≥1/2 muscular layer, n (%) | 29(18.2%) | 63(15.6%) | |
| Lymphovascular invasion | |||
| Absent, n (%) | 125(78.6%) | 280(69.3%) | 0.583 (χ2= 0.436) |
| Present, n (%) | 20(12.6%) | 54(13.4%) | |
| Perineural invasion | |||
| Absent, n (%) | 143(89.9%) | 326(80.7%) | 0.557 (χ2= 1.312) |
| Present, n (%) | 0(0) | 3(0.7%) | |
| Disease stage | |||
| I, n (%) | 138(86.8%) | 279(69.1%) | 0.019 (χ2= 9.796) |
| II, n (%) | 5(3.1%) | 22(5.4%) | |
| III, n (%) | 12(7.5%) | 57(14.1%) | |
| IV, n (%) | 4(2.5%) | 16(4.0%) |
Abbreviations: dMMR, mismatch repair-deficient; POLE, DNA polymerase epsilon; NSMP, no specific molecular profile.