. Author manuscript; available in PMC: 2025 Dec 14.

Published in final edited form as: J Proteome Res. 2025 Nov 10;24(12):6079–6090. doi: 10.1021/acs.jproteome.5c00626

Table 3.

Diagnostic Performance of Combinational Marker with Tetra-Glycoforms * PPV-Positive Predictive Value; NPV-Negative Predictive Value

panel	AUC	95%CI	P-value	specificity	sensitivity	accuracy	PPV	NPV
AFP + Age + A2G2F1S2+A4G4F3S3	Total HCC from Cirrhosis
	0.895	(0.832,0.946)	0.0066	0.800	0.797	0.795	0.797	0.793
AFP + Age + A2G2F1S2+A4G4F3S3+A3G3F3S2.2	Early-HCC from Cirrhosis
	0.911	(0.856,0.960)	0.0049	0.800	0.865	0.821	0.727	0.902
AFP + Age + Gender2+A2G2F1S2+A4G4F3S3	MASLD-HCC from Cirrhosis
	0.942	(0.850,1.000)	0.2244	0.800	1.000	0.902	0.852	1.000