. Author manuscript; available in PMC: 2025 Dec 14.

Published in final edited form as: J Proteome Res. 2025 Nov 10;24(12):6079–6090. doi: 10.1021/acs.jproteome.5c00626

Table 4.

AUCs of Marker-Panels for the Tetra-Antennary Glycoforms Markers and Variables^a

	all HCC vs cirrhosis			early HCC vs cirrhosis			MASLD All HCC vs Cirrhosis
marker panel	AUC (95%CI)	Sens80	p-value	AUC (95%CI)	Sens80	p-value	AUC (95%CI)	Sens80	p-value
AFP	0.756(0.667–0.837)	0.586	reference	0.74(0.631–0.84)	0.557	reference	0.850(0.716–0.958)	0.817	reference
marker-combination	0.702(0.607–0.79)	0.424	0.3999	0.702(0.597–0.801)	0.387	0.6218	0.609(0.432–0.775)	0.348	0.0237
AFP + Age + Gender2+Marker-combination	0.871(0.8–0.931)	0.763	0.0336	0.887(0.815–0.942)	0.703	0.0190	0.901(0.785–0.981)	0.739	0.5228
AFP + Gender2+ marker-combination	0.834(0.754–0.903)	0.644	0.1676	0.825(0.738–0.898)	0.649	0.2100	0.891(0.77–0.983)	0.739	0.6200

Marker-combination: A4G4F3S2+A4G4F1S3+A4G4F3S3+A4G4F2S4; Sens80: the sensitivity when specificity was fixed at 80%; P-values of marker panels were obtained by comparing the ROC curves of the marker panels to that of AFP alone (reference).