. Author manuscript; available in PMC: 2025 Dec 14.

Published in final edited form as: J Proteome Res. 2025 Nov 10;24(12):6079–6090. doi: 10.1021/acs.jproteome.5c00626

Table 5.

Summary of Estimated AUC Values Based on 3-Fold Cross-Validation^a

	combinations with demographic information			combinations without demographic information
data set	training AUC	test AUC	panel	training AUC	test AUC	panel
all HCC vs Cirrhosis	0.897	0.877	AFP + Age + A2G2F1S2+A4G4F3S3	0.847	0.827	AFP + A2G2F1S2+A4G4F3S3
early HCC vs Cirrhosis	0.918	0.868	AFP + Age + A2G2F1S2+A4G4F3S3+A3G3F3S2.2	0.849	0.799	AFP +A2G2F1S2+A4G4F3S3+A3G3F3S2.2
MASLD All HCC vs Cirrhosis	0.954	0.886	AFP + Age + Gender2+A2G2F1S2+A4G4F3S3	0.913	0.867	AFP + A2G2F1S2+A4G4F3S3

3-fold cross-validation was conducted to evaluate the performance of the optimal combination panels in Table 3.