TABLE 3.
Acyclovir pharmacokinetic parameters for each treatmenta
| Treatment | Cmax (μM) | Tmax (h) (median) | AUC0-∞ (μM · h) | t1/2 (h) | CLR (ml/min) | Ae (%)b |
|---|---|---|---|---|---|---|
| Control | 23.77 ± 5.94 | 1.25 | 69.50 ± 12.63 | 2.82 ± 0.14 | 349 ± 68 | 46.4 ± 8.6 |
| Cimetidine | 25.70 ± 8.73 | 1.50 | 88.78 ± 18.45 | 2.98 ± 0.20 | 273 ± 51 | 45.9 ± 7.0 |
| Probenecid | 29.12 ± 9.40 | 1.50 | 103.31 ± 25.65 | 3.13 ± 0.23 | 234 ± 59 | 44.8 ± 6.4 |
| Combined | 30.61 ± 9.48 | 1.50 | 121.90 ± 27.01 | 3.16 ± 0.28 | 187 ± 63 | 42.4 ± 9.7 |
a
Values are means ± SD unless otherwise noted.
b
Ae, percentage of the dose recovered as acyclovir in the urine.